Long-term mortality and cardiovascular morbidity increased in some patients with asymptomatic mitral valve prolapse.

M a i n o u t c o m e m e a s u r e s Total mortality, cardiovascular (CV) mortality, and CV morbidity. M a i n r e s u l t s At median follow up of 5.4 years, 96 deaths (11.5%) occurred and 171 patients (20.5%) had CV morbidity. At 10 years, total mortality was 19%, CV mortality was 9%, and CV morbidity was 30%. After adjustment for age, sex, and comorbid conditions, moderate-to-severe MR and ejection fraction < 50% were independent predictors of CV mortality (Table 1). Several prognostic factors independently predicted CV morbidity (Table 2). C o n c l u s i o n s In patients with asymptomatic mitral valve prolapse, mortality and cardiovascular (CV) morbidity increased over time. Several clinical and echocardiographic variables independently predicted total and CV mortality and CV morbidity.